Disordered Fe vacancies and superconductivity in potassium-intercalated iron selenide (K2-xFe4+ySe5)

The parent compound of an unconventional superconductor must contain unusual correlated electronic and magnetic properties of its own. In the high-Tc potassium intercalated FeSe, there has been significant debate regarding what the exact parent compound is. Our studies unambiguously show that the Fe-vacancy ordered K2Fe4Se5 is the magnetic, Mott insulating parent compound of the superconducting state. Non-superconducting K2Fe4Se5 becomes a superconductor after high temperature annealing, and the overall picture indicates that superconductivity in K2-xFe4+ySe5 originates from the Fe-vacancy order to disorder transition. Thus, the long pending question whether magnetic and superconducting state are competing or cooperating for cuprate superconductors may also apply to the Fe-chalcogenide superconductors. It is believed that the iron selenides and related compounds will provide essential information to understand the origin of superconductivity in the iron-based superconductors, and possibly to the superconducting cuprates

Anisotropy characteristics of exposed gravel beds revealed in high-point-density airborne laser scanning data

The aim of this study was to examine the relationship between the anisotropy direction of exposed gravel bed and flow direction. Previous studies have shown that the anisotropy direction of a gravel bed surface can be visually determined in the elliptical contours of 2-D variogram surface (2DVS). In this letter, airborne laser scanning (ALS) point clouds were acquired at a gravel bed, and the whole data set was divided into a series of 6 m × 6 m subsets. To estimate the direction of anisotropy, we proposed an ellipse-fitting-based automatic procedure with consideration given to the grain size characteristic d50 to estimate the primary axis of anisotropy [hereafter referred to as the primary continuity direction (PCD)] in the 2DVS. The ALS-derived PCDs were compared to the flow directions (for both high and low flow) derived from hydrodynamic model simulation. Comparison of ALS-derived PCDs and simulated flow directions suggested that ALS-derived PCDs could be used to infer flow direction at different flow rates. Furthermore, we found that the ALS-derived PCDs estimated from any elliptical contour of the 2DVS exhibited a similar orientation when the contours of the 2DVS reveal the clear anisotropic structure, demonstrating the robustness of the technique

Predicting microRNA precursors with a generalized Gaussian components based density estimation algorithm

<p>Abstract</p> <p>Background</p> <p>MicroRNAs (miRNAs) are short non-coding RNA molecules, which play an important role in post-transcriptional regulation of gene expression. There have been many efforts to discover miRNA precursors (pre-miRNAs) over the years. Recently, <it>ab initio </it>approaches have attracted more attention because they do not depend on homology information and provide broader applications than comparative approaches. Kernel based classifiers such as support vector machine (SVM) are extensively adopted in these <it>ab initio </it>approaches due to the prediction performance they achieved. On the other hand, logic based classifiers such as decision tree, of which the constructed model is interpretable, have attracted less attention.</p> <p>Results</p> <p>This article reports the design of a predictor of pre-miRNAs with a novel kernel based classifier named the generalized Gaussian density estimator (G²DE) based classifier. The G²DE is a kernel based algorithm designed to provide interpretability by utilizing a few but representative kernels for constructing the classification model. The performance of the proposed predictor has been evaluated with 692 human pre-miRNAs and has been compared with two kernel based and two logic based classifiers. The experimental results show that the proposed predictor is capable of achieving prediction performance comparable to those delivered by the prevailing kernel based classification algorithms, while providing the user with an overall picture of the distribution of the data set.</p> <p>Conclusion</p> <p>Software predictors that identify pre-miRNAs in genomic sequences have been exploited by biologists to facilitate molecular biology research in recent years. The G²DE employed in this study can deliver prediction accuracy comparable with the state-of-the-art kernel based machine learning algorithms. Furthermore, biologists can obtain valuable insights about the different characteristics of the sequences of pre-miRNAs with the models generated by the G²DE based predictor.</p